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tecovirimat will raise the stage or effect of diazepam by affecting hepatic enzyme CYP2C19 metabolism. Use Warning/Check. Tecovirimat is a weak inhibitor of CYP2C8 and CYP2C19. Observe for adverse results if coadministered with sensitive substrates of those enzymes.Outcome of coadministration of a twin CYP3A4 and CYP2C19 inhibitor with fedratinib h